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KMID : 0361720050160020146
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Korean Journal of perinatology
2005 Volume.16 No. 2 p.146 ~ p.153
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Clinical Analysis of 739 Cases of Midtrimester Amniocentesis
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Chun Yea-Young
Ku Jin-Young
Song Jung-Wha
Kim Byoung-Sun
Bae You-Young
Sun Jin-Gyu
Kee Kwang-Soo
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Abstract
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Objective : To analyze the change of indications and chromosomal abnormalities according to patient’s age and indications in midtrimester genetic amniocentesis.
Methods : This study was reviewed 739 genetic amniocentesis results which were performed at Kwangju Christian Hospital from 1995 to 2004, as prenatal genetic diagnosis for the possibility of chromosomal abnormality of fetus. Age distribution, gestational weeks, indications of amniocentesis and cytogenetic results were the key factors for the analysis.
Results : Maternal ages were ranged from 25 to 45, mostly 25~39, Of indications of prenatal genetic mniocentesis, abnormal maternal serum marker was the most common (49.8%), and followed by advanced maternal age (31.1%). The frequency of abnormal karyotypes was 4.6% (34/739). The incidence of abnormal karyotype according to indication had statistical significance in abnormal ultrasonographic finding.
Conclusion : Among the several indications for prenatal cytogenetic diagnosis, ultrasonographic abnormalities and abnormal maternal serum markers might be important indications. Especially, ultrasonographic abnormalities could be the predictive markers for abnormal fetal karyotypes.
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KEYWORD
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Genetic amniocentesis, Chromosomal abnormality, Prenatal diagnosis
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